Matt Barkley, QB, Chicago Bears. With Cutler and Hoyer both injured, it's Barkley's turn to take the reigns for the season. Barkley's not a long-term answer for your fantasy team, but he's an intriguing hold right now. He might struggle given some of the holes in Chicago's team; he struggled in his first stint under center as a Bear. That being said, with more experience in the offense, he could put up a decent week.
Jared Goff, QB, LA Rams. Don't let Goff's lackluster first start scare you off. I think the upside is there for him to put up good numbers down the stretch. The kid has Matt Ryan-type talent, and that talent could show up when everything clicks for him in the NFL. He's worth a speculative add.
Ryan Tannehill, QB, Miami Dolphins. I've never been a huge Tannehill fan, but he has a nice matchup against the 49ers this week. If you're grasping at straws, he's a good one to latch onto. You could do much worse this week.
Scott Tolzien, QB, Indianapolis Colts. Tolzien is a bit of a desperation play in the Indy offense, but if the waiver wire is barren and you're a gambling type, he's worth a roll of the dice since he will likely be starting in Indy this week.
Carson Wentz, QB, Philadelphia Eagles. Wentz is still available in a lot of leagues, especially small leagues. If you're dealing with uncertainty under center and Wentz is available, he might be your best option this week.
Kenneth Dixon, RB, Baltimore Ravens. Sooner or later, Dixon is going to break out in a huge way with a monster game. Pick him up before that happens against you.
Mike Gillisee, RB, Buffalo Bills. Gillisee is a speculative add in that he might not see much of an increase in workload this week, but watch the situation closely in Buffalo as we near game day. Gillisee could put up a nice game if he emerges with a large workload.
Tim Hightower, RB, New Orleans Saints. Hightower seems to have established himself as the top RB in New Orleans. Go get him now if he's still available.
Adrian Peterson, RB, Minnesota Vikings. Peterson is targeting a return from injury to the Vikings in December. If he's available in your league, he needs to be rostered immediately. He might not take another snap this season, but if he does, you want it to be for your team.
Wendell Smallwood, RB, Philadelphia Eagles. Smallwood should see a sizeable number of looks this week thanks to injuries in Philly. That makes him an enticing fantasy option in all scoring formats. Pick him up now.
Tyler Boyd, WR, Cincinnati Bengals. Andy Dalton has to throw to someone this week, and Tyler Boyd should be his main WR target. Boyd should put up solid numbers as the de facto #1 receiver in this unit. He's worth starting.
Tyreek Hill, WR, Kansas City Chiefs. Hill is looking solid in Kansas City. He's put up some fantastic numbers the past few weeks, and should continue that trend this week. If you're hurting at WR and miss out on Boyd, Hill could be your guy this week.
Tajae Sharpe, WR, Tennessee Titans. Sharpe finally had a breakout game this week. Will it continue? If it does, he could put up some great fantasy numbers down the stretch. If you need a flex start or want to fill a roster spot, Sharpe is your guy.
Jared Cook, TE, Green Bay Packers. Cook had a huge game against the Redskins, and that bodes well for his future production with Green Bay. If things are clicking for him, then now is the time to have him on your roster.
Buffalo Bills D/ST. This week, the Bills face the Jaguars. As solid as this Bills unit has been, they should put up a nice game against Jacksonville.
New York Giants D/ST. This week, the Giants get to play the Browns. Enough said.
Tennessee Titans D/ST. This is a unit that could put up some sneaky good numbers against a Bears offense on their third starting quarterback for the year. Worth a spot start.